The effect of propolis on the incidence of peritonitis in patients on continuous ambulatory peritoneal dialysis

Not Applicable

Conditions: Generalized (acute) peritonitis
Peritonitis.

Registration Number: IRCT20110427006318N10

Lead Sponsor: Semnan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 90

Inclusion Criteria

Patients aged 18-60 years
At least history of three months peritoneal dialysis
Lack of acute infections
At least 2-4 sessions of peritoneal dialysis per day
Lack of history of hypersensitivity to honey

Exclusion Criteria

Other sites of infections
Catheter exit site infection
Tunnel infection or peritonitis in the previous month
Antibiotic therapy over the past four weeks
Carriers of staphylococcus aureus
History of psychiatric illness
Cognitive disorder

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peritonitis is evaluated in the presence of Cloudy fluid, abdominal pain, white blood cell count of more than 100/ mm3 (at least 50% neutrophils), fever, and positive fluid dialysis culture. Timepoint: The patient will be assessed every two weeks for peritoneal dialysis. An aliquot of peritoneal effluent and a swab of exit site will be sent for culture monthly and in occasion of appearance of exit site secretion or peritonitis. The duration of assessment will continue for 6 months. Method of measurement: Symptoms of peritonitis are evaluated according to the International Society for Peritoneal Dialysis (ISPD) criteria.

Secondary Outcome Measures

Name	Time	Method
Exit site of catheter and tunnel are monitored for signs of infection (redness, pain, warmness and swelling, secretion from the exit site of the catheter). Timepoint: The patient will be assessed every two weeks for infection signs. Monthly and with signs of infection and peritonitis, the culture of the catheter exit site and the dialysis output fluid will be sent for 6 months. Method of measurement: Inspection of redness, pain, warmness and swelling, secretion from the exit site of the catheter.