Modulation of cough sensitivity using auricular stimulation in stroke: a randomised pilot trial

Yusuf Ozgur Cakmak0 个研究点目标入组 7 人开始时间: 2023年3月13日最近更新: 2024年9月9日

适应症

试验速览

暂无简介。

•Inclusion criteria are as follows: (1) diagnosis of cerebrovascular accident; (2) reduced cough reflex sensitivity (defined as absence of two consecutive strong coughs within 15 seconds of initiating 0.6 mol/L citric acid delivery during clinical natural cough reflex test, on 2/3 trials); and (3) ability to follow study directions and provide informed consent given supported decision-making.

•Due to possible effects on cough sensitivity, participants will be excluded if they have history of other neurological or respiratory diseases that might impact cough function; have poorly-controlled reflux; are currently taking opioid pain or angiotensin-converting enzyme (ACE) inhibiting drugs; had a recent (< 2 weeks) acute upper respiratory tract infection; or are a current or previous smoker.
•Due to safety considerations when receiving auricular stimulation, participants will be excluded if they are pregnant or trying to get pregnant; or have an implanted electrical device (e.g., pacemaker).
•Due to possible risk of bronchoconstriction during citric acid cough reflex test, participants will be excluded if they have asthma; history of respiratory disease; or intolerance/insensitivity to citric acid or citrus fruits.

发起方

Yusuf Ozgur Cakmak