Schizophrenia and MUscarinic Receptor Functioning
Recruiting
- Conditions
- PsychosisCognition
- Registration Number
- NL-OMON28658
- Lead Sponsor
- Academic Medical Center (AMC)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
Patients with first-episode psychosis as defined by the standardised criteria of the CASH
-Medication free
Exclusion Criteria
-Use of antipsychotics and anticholinergics
-Contraindications for MRI
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -M1 receptor binding: ROI’s will be the hippocampus, striatum, anterior cingulate cortex and the dorsolateral prefrontal cortex.
- Secondary Outcome Measures
Name Time Method -BOLD signal activation during cognitive tasks (PAL, visual learning and memory) and ERT (social cognition) under colinergic challenge and in placebo. (ROI’s DLPFC and the hippocampus). <br /><br>-Neuropsychological tests: CANTAB battery for schizophrenia.<br /><br>-DTI <br /><br>-RSfMRI<br /><br>-MRS <br /><br>-genetics<br />