Treatment of Relapsed Low-Grade or Follicular Lymphoma With Rituximab (Also Known as Rituxan, IDEC-C2B8, IDEC-102)
- Conditions
- Low-Grade or Follicular B-Cell Non-Hodgkin's Lymphoma
- Registration Number
- NCT00168740
- Lead Sponsor
- Biogen
- Brief Summary
Rituximab is an antibody made in a laboratory. It binds to lymphoma cells and kills them. Treatment of recurrent B-cell lymphoma with rituximab may delay or prevent relapses. A total of 166 patients with recurrent B-cell lymphoma were given intravenous rituximab once a week for 4 weeks. The patients' tumors were measured before and after treatment. Ten patients had a complete response and 70 patients had a partial response to rituximab. The median duration of response was 11.2 months.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 150
- Diagnosis of relapsed, low-grade or follicular B-cell lymphoma
- CD20-positive lymphoma
- Progressive, measurable disease
- Sign informed consent
- 3 weeks beyond standard therapy
- Good performance status
- Adequate hematologic, renal, and hepatic function
- Chronic lymphocytic leukemia
- Lesions greater than or equal to 10 cm in diameter
- CNS lymphoma
- AIDS-related lymphoma
- Pleural effusions or ascites secondary to lymphoma
- Active, opportunistic infection
- Serious nonmalignant disease
- Prior investigational therapies, including prior anti-CD20 therapy
- Recent major surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method overall response rate
- Secondary Outcome Measures
Name Time Method time to disease progression progressive disease-free interval
Trial Locations
- Locations (31)
University of Arkansas for Medical Sciences
🇺🇸Little Rock, Arkansas, United States
City of Hope Natioal Medical Center
🇺🇸Duarte, California, United States
Scripps Memorial Hospital
🇺🇸La Jolla, California, United States
UCSD Stem Cell Laboratory
🇺🇸La Jolla, California, United States
Hoag Hospital
🇺🇸Newport Beach, California, United States
Sutter Cancer Center
🇺🇸Sacramento, California, United States
Sidney Kimmel Cancer Center
🇺🇸San Diego, California, United States
University of California, San Francisco
🇺🇸San Francisco, California, United States
Stanford University Medical Center
🇺🇸Stanford, California, United States
Kaiser Permanente Medical Center
🇺🇸Vallejo, California, United States
Scroll for more (21 remaining)University of Arkansas for Medical Sciences🇺🇸Little Rock, Arkansas, United States