Antenatal Umbilical Cord Coiling Indexand Perinatal Outcome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Small for gestational age
研究概览
简要总结
Umbilical cord is a narrow cord of tissue that connects a developing foetus with the placenta
One important feature of the umbilical cord is its coiling index (UCI).
A coil is defined as completed 360 degrees spiral course of umbilical vessels around Wharton’s jelly.
The cause of abnormal cord coiling is not known.
Abnormal cord coiling was associated with thrombosis of chorionic plate vessels, umbilical venous thrombosis, and cord stenosis.
Umbilical coiling affects the venous return to the fetus,
Hypo-coiling leads to reduced venous return and is associated with reduced flow indices in the umbilical vein
Effects on fetal well-being are chronic (growth retardation) and acute (fetal intolerance to labor and fetal demise).
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Female
入选标准
- •Healthy women with singleton live foetuses with no maternal and fetal complications detected at late second trimester(18-28 weeks)and early 3rd trimester for doppler evaluation(28-32 weeks) with no gross fetal anomalies.
排除标准
- •Multiple gestations Pregnancy with medical disorders (chronic hypertension, overt diabetes, cardiac disease, hepatic and renal impairment) Low AFI (<5cm).
结局指标
主要结局
Small for gestational age
时间窗: at 18 weeks period of gestation i will measure umbilical cord coiling via ultrasound and i will measure velocity of blood flow in umbilical vein at 28 weeks of gestation and correlate with outcome variables immediate post delivery
Intrauterine growth retardation (IUGR)
时间窗: at 18 weeks period of gestation i will measure umbilical cord coiling via ultrasound and i will measure velocity of blood flow in umbilical vein at 28 weeks of gestation and correlate with outcome variables immediate post delivery
Preterm delivery
时间窗: at 18 weeks period of gestation i will measure umbilical cord coiling via ultrasound and i will measure velocity of blood flow in umbilical vein at 28 weeks of gestation and correlate with outcome variables immediate post delivery
APGAR scores 7 at 5min
时间窗: at 18 weeks period of gestation i will measure umbilical cord coiling via ultrasound and i will measure velocity of blood flow in umbilical vein at 28 weeks of gestation and correlate with outcome variables immediate post delivery
Presence of meconium-stained amniotic fluid
时间窗: at 18 weeks period of gestation i will measure umbilical cord coiling via ultrasound and i will measure velocity of blood flow in umbilical vein at 28 weeks of gestation and correlate with outcome variables immediate post delivery
Delivery intervention due to fetal distress(Instrumental/caesarean section)
时间窗: at 18 weeks period of gestation i will measure umbilical cord coiling via ultrasound and i will measure velocity of blood flow in umbilical vein at 28 weeks of gestation and correlate with outcome variables immediate post delivery
次要结局
未报告次要终点