Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

• Conditions: Sperm Capacitation
• Interventions: Other: biologic; Other: sperm capacitation

• Registration Number: NCT00731159
• Lead Sponsor: Assaf-Harofeh Medical Center

Brief Summary

Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments

Detailed Description

Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.

Study Timeline

• Status Verified: 2008-07
• Study Start: 2008-07
• Study First Submitted: 2008-08-07
• Study First Submitted QC: 2008-08-07
• Last Update Submitted: 2008-08-07
• Study First Posted: 2008-08-08
• Last Update Posted: 2008-08-08
• Primary Completion: 2009-01
• Study Completion: 2009-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients requiring IVF within the "routine" work of an IVF Unit
• normo-responding woman
• non ICSI cycles

Exclusion Criteria

• Patients undergoing ICSI only cycle
• Low responders-less than 8 oocytes
• Male patients with low semen volume

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
A	biologic	Sperm capacitation: Sperm capacitation is measured in a sample of the same ejaculated sperm unit given for fertilizing human oocytes in an IVF treatment cycle
A	sperm capacitation	Sperm capacitation: Sperm capacitation is measured in a sample of the same ejaculated sperm unit given for fertilizing human oocytes in an IVF treatment cycle

Primary Outcome Measures

Name	Time	Method
Fertilization rate of human oocytes in thr "routine" IVF Laboratory work	One year

Trial Locations

Locations (1)

Assaf Harofeh MC; 🇮🇱 Beer Yaacov, Zerifin, Israel