Recognizing patients with (a higher risk of) endometrial cancer; the role of fat distribution and inflammation in the origin of endometrial cancer, a study that focuses on prevention and predictio
- Conditions
- Endometrial cancer
- Registration Number
- NL-OMON28456
- Lead Sponsor
- AAF (Academic Alliance Foundation)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 160
Inclusion Criteria
CASES (n=80): - pre- and perimenopausal BMI =35 (n=20)
- pre- and perimenopausal BMI 18-25 (n=20)
- postmenopausal BMI =35 (n=20)
- postmenopausal BMI 18-25(n=20)
Exclusion Criteria
- Other malignancy <5 years prior to inclusion, except basal cell carcinoma
- Use of systemic hormonal therapy <3 months
- Insufficient understanding of the Dutch language
- Subjects not allowed to undergo CT-scan
- Women (cases as well as controls) with BMI between 25.1-34.9
- Women who are expected to be offered HRT after surgery
CONTROLS (n=80): - Pre- and perimenopausal BMI =35 (n=20)
- Age >40 years
- pre- and perimenopausal BMI <25 (n=20)
- postmenopausal BMI =35 (n=20)
- postmenopausal BMI 18-25(n=20)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare hormone levels and inflammatory markers before and after BSO in obese and non-obese subjects.
- Secondary Outcome Measures
Name Time Method To compare the effect of fat distribution and etiology on changes in hormone levels and inflammatory markers due to BSO in obese and non-obese subjects as well as the effect of BSO on menopausal complaints.