Ventilation-Perfusion Matching in Early-stage Prone Position Ventilation: A Comparison Between COVID-19 ARDS and ARDS From Other Etiologies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 1
- 主要终点
- Shunt
研究概览
简要总结
Prone positioning has been widely used in critical care medicine to improve oxygenation in patients with acute respiratory distress syndrome (ARDS). This study aimed to compare the effect of pronation on lung ventilation-perfusion matching between COVID19-associated acute respiratory distress syndrome (CARDS) and ARDS from other etiologies (non-CARDS) using electrical impedance tomography (EIT).
详细描述
In this prospective study, both COVID19-associated ARDS (CARDS) patients and patients with ARDS from other etiologies (non-CARDS) were enrolled. Electrical impedance tomography (EIT) was used to evaluate the changes in ventilation and perfusion between supine and prone positions. Baseline values of the area of DeadSpace, shunt, ventilation-perfusion matching (VQmatch) were identified at the time of enrollment. Within the defined VQmatch region, the global inhomogeneity index (VQmatch-GI) was calculated to assess the degree of uniformity within the region. Prone position was applied immediately after the baseline data were collected. After 2 hours of proning, another EIT examination was conducted. Parameters such as DeadSpace, shunt, VQmatch, and other common measurements before and after pronation were taken and compared to evaluate the effect of prone positioning on CARDS and non-CARDS patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Above the age of 18
- •Diagnosed with ARDS based on the Berlin Definition of ARDS
- •Under mechanical ventilation
排除标准
- •Contraindications to EIT examination and prone position
- •Refusal of signing the informed consent
结局指标
主要结局
Shunt
时间窗: 3 months
Shunt will be assessed using electrical impedance tomography
Global inhomogeneity index (VQmatch-GI)
时间窗: 3 months
Within the defined VQmatch region assessed by electrical impedance tomography, the global inhomogeneity index (VQmatch-GI) was calculated to assess the degree of uniformity within the region.
DeadSpace
时间窗: 3 months
The area of Deadspace will be assessed using electrical impedance tomography
Ventilation-perfusion matching (VQmatch)
时间窗: 3 months
VQmatch will be assessed using electrical impedance tomography
次要结局
- Center of Ventilation (CoV)(3 months)
- Standard deviation of regional ventilation delay(3 months)
- Perfusion(3 months)
- Ventilation(3 months)