Fluorescein-Induced Acute Kidney Injury in Patients With Diabetes and Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Change in serum creatinine
研究概览
简要总结
Our study hypothesizes that fluorescein exposure in diabetic patients with advanced chronic kidney disease results in deterioration of kidney function. It will therefore aim to evaluate the incidence of acute kidney injury induced by fluorescein in diabetic patients with CKD. The objective is to determine the incidence, severity and risk factors associated with this deterioration to improve the care of this specific population.
详细描述
This study will assess the change in serum creatinine in patients with diabetes and advanced chronic kidney disease, after a fluorescein angiography. This is a before and after study that will include 35 patients from the department of ophtalmology over 6 months with a total follow-up for 3 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •>18 years old with type 2 or type 1 diabetes and chronic kidney disease stage 3b to 5 (eGFR<45 mL/min/1.73 m2)
排除标准
- •Patients who do not give their consent
- •Patients who are allergic to fluorescein
- •Patients who are on dialysis
- •Patients who had fever, vomiting, diarrhea or any dehydration 48 hours before the intervention
- •Patients who had a treatment modification one week before the intervention
研究组 & 干预措施
Fluorescein angiography
Assessing serum creatinine before and after fluorescein angiography
干预措施: Fluorescein angiography (Diagnostic Test)
结局指标
主要结局
Change in serum creatinine
时间窗: At day 4
Change in serum creatinine from baseline to day 4
次要结局
- Long-term change in serum creatinine(3 months)
研究者
Mabel Aoun
Associate Professor
Saint-Joseph University