Early Detection of Acute Kidney Injury (EDAKI)
- Conditions
- Acute Kidney InjuryAcute Renal FailureCardiac ArrestAbdominal Aortic AneurysmHypotensionRenal and Urogenital - Kidney disease
- Registration Number
- ACTRN12610001012066
- Lead Sponsor
- niversity of Otago Christchurch
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 100
On entry to the ED:
(1)Cardiac Arrest within the preceding three hours AND/OR
(2)Ruptured Abdominal Aortic Aneurysm AND/OR
(3)Sustained hypotension (defined as systolic blood pressure (SBP) <90 mmHg or Mean Arterial Pressure (MAP) < 65 mmHg after 1000ml IV fluid challenge / 60 mins (including Intravenous (IV) fluids pre hospital)) AND/OR
(4)Profound hypotension (Systolic Blood Pressue (SBP) less than 60mmHg) of any duration.
(1)Age<16
(2)Moribund, not expected to survive 24 hours
(3)Likely to be discharged within 24 hours
(4)Drug overdose
(5)Treatment limitation order
(6)Receiving Renal Replacement Therapy
(7)More than 4 hours since entry to ED
(8) Inter-hospital transfer unless arrival in ED within <3 hours of event
(9)Non-consent
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction of False Negative rate for prediction of Acute Kidney Injury (AKI) by sampling on entry to the Emergency Department (ED) compared with on entry to the Intensive Care Unit (ICU)[Comparison between on entry to ED compared with on entry to ICU]
- Secondary Outcome Measures
Name Time Method Receiver Operator Characteristic (ROC) plot analysis (receiver-operating characteristic) will be used to compare the discriminative power of the biomarkers for AKI, need for Renal Replacement Therapy (RRT), Death (30 day).[On entry to ED. On entry to the ICU. During ICU stay (7 days)]