NCT03171675已完成不适用
Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- Interleukin-17
研究概览
简要总结
This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Interleukin-17 is a pro-inflammatory cytokine whose levels have been proven to increase in periodontal disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Within the age range of 18-35 years
- •Free of any systemic diseases as referenced from Burket's Oral Medicine health history questionnaire (Glick2008)
- •Spontaneous normal term birth at ≥37 weeks of gestation without any obstetrical or medical complications
- •Spontaneous preterm birth (PTB) at <37 weeks of gestation after uterine contraction or rupture of membranes (Keelan1999)
排除标准
- •History of medications that may affect the study outcome, such as: current use of systemic corticosteroids or antibiotics for at least one month
- •Genital and urinary tract infections
- •Existing hypertension and diabetes mellitus before pregnancy, autoimmune disease, asthma, and chronic renal disease
- •Multiple pregnancies, cervical cerculage, abnormal placentation, past history of preterm delivery, or antepartum hemorrhage
- •Low or high maternal body mass index
结局指标
主要结局
Interleukin-17
时间窗: Single sample from each patient following birth
Interleukin-17 levels in gingival crevicular fluid and placental tissue samples
次要结局
未报告次要终点
研究者
Mohamed Agoor
Principal Investigator
Ain Shams University
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