NCT03449186已完成不适用
Interleukin-17 and Th17 Inducing Cytokines Exacerbate Periodontal Disease During Pregnancy and Postpartum
Aydin Adnan Menderes University0 个研究点目标入组 114 人开始时间: 2013年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 114
- 主要终点
- Changing Il-17A levels
研究概览
简要总结
The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of IL-17A, IL-17E, IL-6 AND IL-23 during 2/3 trimester of pregnancy and after delivery.
详细描述
IL-17 have a synergytic effect with IL-6 and IL-23. IL-17A levels elevated with periodontal diseases. Many systemical chronic conditions such as atherosclerosis and cardiovascular disease, pregnancy may contribute increasing of IL-17 family cytokine.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women 2 and 3 trimester of their pregnancy
排除标准
- •any known systemic disease,
- •periodontal treatment within the last six months,
- •patients having less than 10 teeth,
- •individuals with a BMI > 30 kg/m2,
- •gestational diabetes and preeclampsia during pregnancy.
结局指标
主要结局
Changing Il-17A levels
时间窗: 6 month
Salivary and GCF level measured by ELISA
次要结局
- Changing IL-6 levels(6 month)
- Changing IL-23 levels(6 month)
- Changing IL-17E levels(6 month)
研究者
Veli Özgen Öztürk
Principal Investigator
Aydin Adnan Menderes University
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