Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages
- Registration Number
- NCT01419392
- Lead Sponsor
- Ain Shams University
- Brief Summary
The purpose of this study is to determine whether sildenafil citrate is effective in improving uterine artery blood flow and oxidative stress in patients with unexplained recurrent miscarriages
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 80
Inclusion Criteria
- Age 18-35 years
- Three or more recurrent miscarriages before the 24th week of gestation with no apparent cause for their previous losses
- Three or more months have elapsed since the last abortion
- Postmenstrual period
- No other therapy allowed during our treatment course
Exclusion Criteria
- Concomitant use of organic nitrites, or nitrates
- Severe hepatic, renal, or cardiovascular impairment
- History of stroke or myocardial infarction
- Patients with retinitis pigmentosa.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sildenafil citrate Sildenafil citrate - placebo matching placebo -
- Primary Outcome Measures
Name Time Method Uterine arteries blood flow 21 days Uterine arteries blood flow assessed by Doppler U/S by measuring Systolic / diastolic ratio, pulsatility index and resistance index
- Secondary Outcome Measures
Name Time Method Nitric oxide serum level as a marked of oxidative stress 21 days Total antioxidant capacity serum level as a marker of oxidative stress 21 days
Trial Locations
- Locations (1)
Ain Shams University Maternity Hospital, Obstetrics and Gynecology Department
🇪🇬Cairo, Egypt