Effect Of Palonosetron In The Prevention Of Spinal Anaesthesia Induced fall in Blood pressure and Heart rate.
Phase 3
- Conditions
- Health Condition 1: R688- Other general symptoms and signs
- Registration Number
- CTRI/2021/01/030524
- Lead Sponsor
- kalinga institute of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients Of ASA Grade I & II Posted For Surgeries Under Spinal Anaesthesia
Exclusion Criteria
1.Hypertension on medication
2.Diabetic neuropathy
3.Pregnancy
4.BMI > 30
5.Patients receiving selective serotonin
reuptake inhibitors or migraine medication
6.Patient refusal
7.Hypersensitivity to palonosetron.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measuring systolic blood pressure, Diastolic blood pressure, and Mean blood pressure at 3 min interval. Measuring Heart rate continuouslyTimepoint: Measuring systolic blood pressure, Diastolic blood pressure, and Mean blood pressure at 3 min interval. Measuring Heart rate continuously
- Secondary Outcome Measures
Name Time Method To assess the need of vasopressorsTimepoint: every 3 minute interval
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms does palonosetron target to prevent spinal anaesthesia-induced hypotension and bradycardia?
How does palonosetron compare to vasopressors like phenylephrine in preventing hypotension during spinal anaesthesia?
Are there specific biomarkers that predict patient response to palonosetron in spinal anaesthesia settings?
What adverse events are associated with palonosetron use in spinal anaesthesia and how are they managed?
What other 5-HT3 receptor antagonists or combination therapies are being explored for managing spinal anaesthesia-induced hypotension?