跳至主要内容
临床试验/NCT01805349
NCT01805349已完成不适用

Study of the Association Between Digital Osteoarthritis and Lower Limb Osteoarthritis (Knee and Hip) in Terms of Severity and Evolution - Khoala Group Ancillary Project / Cohort Khoala

Centre Hospitalier Universitaire de Nice1 个研究点 分布在 1 个国家目标入组 479 人开始时间: 2013年11月4日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
479
试验地点
1
主要终点
Kellgren and Lawrence score

研究概览

简要总结

Among the risk factors for lower limb osteoarthritis, if obesity is probably the most studied, digital osteoarthritis received increasing interest in recent years. Recent publications have highlighted a link between obesity and digital osteoarthritis, but also a very probable link between digital osteoarthritis and structural progression of knee osteoarthritis. Few data including hip exist and need to be confirmed on larger scale studies. We have with "Khoala" a national multiregional cohort of symptomatic gonarthrosis and coxarthrosis representative of the general population (which is rarely the case in the literature) including X ray, clinical and biological follow-up (hips and / or knees).

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
40 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • men or women aged 40 to 75 years
  • with symptomatic osteoarthritis of the hip and / or knee (femoro-tibial), unilateral or bilateral
  • with a confirmed diagnosis (criteria of the American College of Rheumatology :ACR) and Kellgren and Lawrence radiological stage ≥ 2.

排除标准

  • painful hip or knee prosthesis
  • osteotomy in the past

结局指标

主要结局

Kellgren and Lawrence score

时间窗: Change at 2 years

Kellgren and Lawrence score for hip or knee

次要结局

  • Harris score(Harris score at 2 years)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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