Obesity and Initiation of Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 177
- 试验地点
- 1
- 主要终点
- Cartilage Thickness
研究概览
简要总结
Healthy adults aged 20-60 of varying weights will participate in this minimally invasive study. There is one 4-hour appointment for which subjects are paid $120. The tests involve: 1 tube blood draw, 1 gait test (motion capture) and 1 MR of both knees.
详细描述
The tests will be done at the VA and Stanford and are not dangerous or painful. They are designed to help us learn more about the relationship of excess weight on cartilage degradation by testing a biomarker in blood. Gait testing involves walking in a lab that is about 20 meters long about 20 times. MR involves lying in a tube for less than 1 hour.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy Adults aged 20-60 who have no history of LE surgery
- •Healthy adults able to walk 30 minutes
- •Healthy adults able to have MR
排除标准
- •Adults who have had LE surgery
- •Adults cannot walk 30 minutes
- •Adults who cannot tolerate MR
- •Adults with osteoarthritis
结局指标
主要结局
Cartilage Thickness
时间窗: baseline or first and only visit.
Medial/lateral thickness ratio
Gait Knee Adduction Moment
时间窗: baseline or first and only visit.
次要结局
未报告次要终点