ACTRN12618000361202
Completed
Phase 4
A Prospective Randomised Controlled Pilot Trial of Preoperative Microvascular Protection in Patients Undergoing Major Abdominal Surgery
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Glycocalyx degradation
- Sponsor
- Austin Health
- Enrollment
- 72
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adults aged \> 18 years
- •Undergoing elective open bowel resection, pancreatic resection or liver resection surgery
- •Requiring a hospital stay of at least one postoperative night
- •Routine use of arterial line for continuous blood pressure monitoring and intermittent positive pressure ventilation via an endotracheal tube as part of standard anaesthesia care
- •American Society of Anesthesiologists (ASA) Physical status \<5
Exclusion Criteria
- •Poorly controlled diabetes (HbA1c \> 9\.0% or HbA1c \>75 mmol/mol) if known
- •Allergy to albumin or dexamethasone
- •Surgery is being performed for treatment of an infective process (e.g. intra\-abdominal sepsis)
- •Planned postoperative intubation or ventilation
- •Concurrent immunosuppressive therapies or immunosuppressed state
- •Chronic steroid use (prednisolone 10mg/day or equivalent for greater for \>1 week in preceding 3 months)
- •Pregnant or lactating woman
- •Surgical procedures within the preceding 2 months or expected within the subsequent 30 days
Outcomes
Primary Outcomes
Not specified
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