Impact of Preoperative Frailty and Cognitive Impairment on Postoperative Outcomes in Elderly Cardiac Surgery Patients

Completed

• Conditions: Cardiovascular Diseases

• Registration Number: NCT06330532
• Lead Sponsor: Yonsei University

Brief Summary

This is a retrospective study of patients aged 65 years and older who underwent cardiac and aortic surgery between March 5, 2021 and October 12, 2022 in the operating room of Severance Cardiovascular Hospital to determine the impact of physical frailty as well as nutritional status, emotional dysregulation, and cognitive dysfunction on postoperative outcomes. Physical frailty will be determined by the Clinical Frailty Scale, handgrip strength, and nutritional status, cognitive dysfunction will be determined by the K-MMSE and K-MoCA administered at the preoperative interview, and emotional dysregulation will be determined using the SGDS-K. These were measured during the pre-anesthesia evaluation and only results from patients who agreed to be tested will be used. Nutritional status will be analyzed based on blood test values measured within one month of surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-03-01
• Study First Submitted: 2024-03-19
• Study First Submitted QC: 2024-03-25
• Study First Posted: 2024-03-26
• Primary Completion: 2024-04-05
• Study Completion: 2024-10-01
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-09
• Last Update Posted: 2025-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 447

Inclusion Criteria

• 65-year-old patients undergoing surgery for heart and aortic disease, who completed physical (Clinical Frailty scale, Handgrip strength), cognitive(K-MoCA, K-MMSE), and emotional (SGDS-K) functioning tests at the preoperative interview

Exclusion Criteria

• Failed to complete two or more of assessments shown above

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
postoperative all cause mortality	within 1 year	This study evaluates all-cause mortality within 1 year after surgery
major composite morbidity	within 30days after surgery for major composite morbidity

Secondary Outcome Measures

Name	Time	Method
the number of days not in hospital	90 days	DAOH is the number of days not in hospital over a defined postoperative period
The number of participants who die	30 days after surgery	patients who die

Trial Locations

Locations (1)

Yonsei University Health system, Severance Hospital; 🇰🇷 Seoul, Korea, Republic of