A comparative study to evaluate the effectiveness of nebulised dexmedetomidine versus nebulised lignocaine the haemodynamic response to awake fiberoptic intubation in patients of head & neck cancers.
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Systolic blood pressure Diastolic blood pressure
研究概览
简要总结
This study aims to compare the effectiveness of nebulised Lignocaine (4 ml of 2% lignocaine) and dexmedetomidine (1µm/kg in 4 ml of normal saline) to blunt the haemodynamic response (as a marker of surface anaesthesia) in patients of head & neck cancers undergoing general anaesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Additional Inclusion Criteria
- •ASA grade 1 and II
- •BMI more than 18kg/m2 and below 29kg/m2
- •Elective surgeries under general anaesthesia
- •Who had given valid informed consent
- •All MP grades including patients with zero mouth opening.
排除标准
- •Patient refusal
- •BMI not between 18kg/m2 29kg/m2
- •Patient allergic to lignocaine or its preservative
- •Emergency surgery and history of laryngeal and pharyngeal surgery.
结局指标
主要结局
Systolic blood pressure Diastolic blood pressure
时间窗: Pre operative period (Before start of nebulisation) | during procedure (Fiberoptic intubation) | then after 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 and 20 minutes.
Heart rate
时间窗: Pre operative period (Before start of nebulisation) | during procedure (Fiberoptic intubation) | then after 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 and 20 minutes.
Mean Arterial Pressure
时间窗: Pre operative period (Before start of nebulisation) | during procedure (Fiberoptic intubation) | then after 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 and 20 minutes.
次要结局
- side effects associated with the use of these drugs(Pre operative period (Before start of nebulisation))
研究者
Mohd Asim Rasheed
Kalyan Singh Superspeciality Cancer Institute