Cerebral Microembolism in the Critically Ill With Acute Kidney Injury: A Prospective Multi-Center Randomized Controlled Trial Comparing Continuous With Intermittent Renal Replacement Therapy.

Insel Gruppe AG, University Hospital Bern1 site in 1 country66 target enrollmentJanuary 2017

ConditionsCerebral Embolism

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Cerebral Embolism
Sponsor: Insel Gruppe AG, University Hospital Bern
Enrollment: 66
Locations: 1
Primary Endpoint: Cerebral Microembolic Load detected by Transcranial Doppler Ultrasound
Status: Terminated
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.

Registry

clinicaltrials.gov

Start Date

January 2017

End Date

November 6, 2022

Last Updated

3 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Insel Gruppe AG, University Hospital Bern

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•\> 18 yrs.
•Signed IC

Exclusion Criteria

•Heart disease (PFO, ASD, VSD, severe valvular disease)
•Atrial fibrillation
•Cerebrovascular pathology
•Missing temporal bone window
•Allergy to plastic contained in the investigative device (transcranial Doppler)
•Chronic kidney disease
•Pregnancy
•Participation in another study