Quantity, Quality and Laterality of Cerebral Microembolism During Veno-Venous Hemodialysis.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Quantity of cerebral embolic load
研究概览
简要总结
There is increasing evidence that renal replacement therapy (= continuous veno-venous hemodialysis) generates cerebral microembolism which is detectable on transcranial Doppler ultrasound.
The aim of this study is to monitor patients with transcranial Doppler under two conditions: during hemodialysis and in a hemodialysis-free interval (in each period cerebral embolic load is detected during 30 minutes).
The study hypothesis is that during hemodialysis the cerebral embolic load is significantly higher than in the hemodialysis-free interval.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Renal replacement therapy (continuous veno-venous hemodilalysis) on the in-house intensive care unit
- •Age > 18yrs and < 90yrs
排除标准
- •Absent informed consent
- •Preexistent neurological morbidity
- •Neurocognitive disturbances
- •Carotid artery stenosis > 70%
- •Patent foramen ovale
- •Treatment with other extracorporeal devices
- •Cardial pathology (valvular heart disease, prosthesis, endocarditis)
- •Pregnancy, drug abuse
- •Inclusion in an other clinical study
- •Allergy against materials of the medical device used in the study (transcranial Doppler) or temporal skin/bone lesions
结局指标
主要结局
Quantity of cerebral embolic load
时间窗: 30 minutes
Cerebral embolic load is measured in a 30 minutes-interval during hemodialysis and in a hemodialysis-free interval.
次要结局
- Quality and laterality of cerebral embolic load(30 minutes)
研究者
Dr. Gabor Erdoes
Dr Gabor Erdoes
Medical University of Vienna