Substudy of the Leipzig Immediate Versus Early and Late Percutaneous Coronary Intervention Trial in NSTEMI - LIPSIA-NSTEMI TRIAL
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- NSTEMI
- Sponsor
- University of Jena
- Enrollment
- 602
- Locations
- 1
- Primary Endpoint
- MACE
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
It is assumed that patients with non-ST-elevation myocardial infarctions (NSTEMI) showing an infero- or posterolateral occluded culprit artery (OCA) during diagnostic angiography frequently elude standard 12-lead electrocardiogram diagnosis. In addition, coronary collaterals may have beneficial effects in patients with OCA.
Detailed Description
We examined consecutive NSTEMI patients within 48 h of symptom onset. All patients underwent early invasive angiography plus optimal medical therapy. We compared baseline characteristics, procedural findings including analysis of TIMI-flow and collaterals using the Rentrop-classification, 30-day and 6-months major adverse cardiovascular events (MACE) in patients with and without totally OCA.
Investigators
Eligibility Criteria
Inclusion Criteria
- •age between 18 and 90 years,
- •onset of angina pectoris at rest \<24 h or crescendo angina in recent weeks with symptoms under minimal exertion or at rest lasting \<24 h,
- •elevated troponin T ≥0.03 µg/L and
- •written informed consent.
Exclusion Criteria
- •persistent angina,
- •ST-segment elevation myocardial infarction (STEMI),
- •hemodynamic instability including cardiogenic shock,
- •oral anticoagulation therapy,
- •contraindications for glycoprotein IIb/IIIa inhibitors,
- •other disease with life expectancy \<6 months,
- •known coagulopathy,
- •pregnancy,
- •other suspected causes of troponin elevation as myocarditis, secondary to hypertensive crisis, or after cardiac decompensation,
- •no ability to consent, and
Outcomes
Primary Outcomes
MACE
Time Frame: 6 months
composite of death, reinfarction and readmission for unstable angina within 6 months after inclusion
Secondary Outcomes
- CK and CK-MB(48 hours)