EEG Characteristics of Different Sedation Depths in Patients With Supratentorial Glioma in Frontal Lobe
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 42
- 试验地点
- 2
- 主要终点
- 1. The time-frequency characteristics of EEG power changes at different sedation depths in neurosurgical patients.
研究概览
简要总结
Gliomas are the most common primary intracranial malignancy, and behavioral experiments in patients with supratentorial gliomas under sedation have shown potential neurological abnormalities; however, these behavioral experiments are susceptible to external influences. Therefore, more objective evidence is needed to support and extend the existing conclusions. The purpose of this study is to compare the EEG signatures (such as the EEG signal power) at various levels of anesthetics induced sedation in patients with supratentorial glioma in frontal lobe and in patients without intracranial-occupying lesion.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with supratentorial glioma in right frontal lobe, and patients requiring general anesthesia without intracranial-occupying lesion;
- •Aged 18-60 years;
- •ASA I to II;
- •All those who sign the informed consent form.
排除标准
- •Obese patients, BMI>30kg/m2;
- •Patients with Mallampati class III to IV airway anatomy;
- •Combined with other neurological or psychiatric diseases;
- •Combined with disturbance of consciousness;
- •Previous intracranial surgery;
- •Known or suspected cardiac dysfunction;
- •Allergic to intravenous general anesthetics;
- •Long-term history of analgesia, sedation and drug abuse.
结局指标
主要结局
1. The time-frequency characteristics of EEG power changes at different sedation depths in neurosurgical patients.
时间窗: Prior to anesthesia induction, three minutes after reaching the target level of sedation
The EEG power will be calculated by raw signal at awake, eye-closed state and after reaching the steady-state sedation depths of OAA/S=3 and OAA/S=1.
次要结局
未报告次要终点
研究者
Ruquan Han
professor
Beijing Tiantan Hospital