anguage and EEG characteristics in brain tumour patients: Can we predict language outcome after surgery? - Language and EEG characteristics in brain tumour patients

Rijksuniversiteit Groningen0 个研究点目标入组 90 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

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•Patient group 1:
•- Diagnosis of a radiologically presumed low-grade glioma; according to the judgement of radiologist, neurosurgeon or neurologist.
•- Location in the language dominant hemisphere (if unknown: right-handed and left-sided tumour)
•- Tumour is untreated
•- Planned to undergo awake brain surgery
•- In case of epilepsy, seizures under control with anti-epileptic drugs (less than six seizures in the previous year and on anti-epileptic monotherapy or polytherapy)
•- Between 18 and 75 years old;Patient group 2:
•- Diagnosis of an intracranial, supratentorial meningioma
•- Location in the left hemisphere
•- Location: falcine and parasaggital meningiomas, when located at the skull base only sphenoid wing, and tentorial meningiomas when located supratentorially
•- Diameter > 3 cm
•- Tumour is untreated
•- Planned to undergo brain surgery
•- Presumed low-grade
•- Language dominance in the left or right hemisphere
•- In case of epilepsy, seizures under control with anti-epileptic drugs (less than six seizures in the previous year and on anti-epileptic monotherapy or polytherapy)
•- Between 18 and 75 years old;Control group (comparable to the patient groups with respect to age, gender and education):
•- right-handed
•- between 18 and 75 years old

•For the patient groups:
•- Non-native speaker of Dutch or insufficient command of the Dutch language
•- History of a medical, neurological or psychiatric condition known to affect language or cognitive functioning
•- (History of) substance abuse
•- Use of medication known to influence language or cognitive functioning, other than anti-epileptic drugs
•- Use of dexamethasone pre-operatively (peri-operatively according to local protocol is not an exclusion criterion)
•- Use of medication known to influence EEG, other than anti-epileptic drugs
•- Previous brain surgery or cranial radiation therapy;For the control group:
•- Non-native speaker of Dutch or insufficient command of the Dutch language
•- History of medical, neurological or psychiatric condition known to affect language or cognitive functioning
•- (History of) substance abuse
•- Use of medication known to influence language or cognitive functioning
•- Use of medication known to influence EEG
•- Previous brain surgery or cranial radiation therapy

发起方

Rijksuniversiteit Groningen