Efficacy and tolerability of two quadruple regimens;bismuth,omeprazole, metronidazole and Amoxicillin or tetracycline as first line treatment for eradication of helicobacter pylori in patients with duodenal ulcer

Phase 2

Completed

• Conditions: helicobacter pyloriQuadruple therapyeradicationdrug resistance; helicobacter pylori; Quadruple therapy; eradication; drug resistance

• Registration Number: TCTR20170623004
• Lead Sponsor: Shahid Sadoughi University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-07-01
• Study Start: 2017-06-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 228

Inclusion Criteria

Patients were eligible if they were aged
18 years or older and had confirmed H pylori infection. H
pylori infection was diagnosed by either a positive rapid urease
test or positive identification of H pylori in a histological sample
using haematoxylin and eosin and/or Giemsa stain

Exclusion Criteria

Patients
were excluded if they had any of the followings: previous eradication
therapy for H pylori; known allergies to any of the study
medications; recent use of antibiotics, bismuth salts, probiotic
preparations, proton pump inhibitors or non-steroidal antiinflammatory
drugs in the preceding 1 month; pregnant or lactating
women; previous gastric surgery; alcohol or drug abuse;
or severe concurrent medical illnesses, such as liver failure, renal
failure or terminal malignancy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
side-effect 2 week after start questionnaire

Secondary Outcome Measures

Name	Time	Method
Eradication of helicobacter pylori 8 weeks after complete treatment C13 urea breath test