Study on the Effect of Selenium Supplementation on the Structure and Function of Autoimmune Thyroiditis

Not Applicable

• Conditions: Selenium
• Interventions: Drug: Selenium

• Registration Number: NCT04942769
• Lead Sponsor: Beijing Chao Yang Hospital

Brief Summary

To evaluate the effects of exogenous selenium supplementation on autoimmune thyroiditis.

Detailed Description

In patients with autoimmune thyroiditis， investigators compared changes in thyroid function, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, thyroid magnetic resonance T1-mapping values and metabolic indicatorsfrom baseline to the end of treatment (12 weeks)

Study Timeline

• Study Start: 2019-12-20
• Study First Submitted: 2021-06-24
• Study First Submitted QC: 2021-06-24
• Study First Posted: 2021-06-28
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-11
• Last Update Posted: 2021-07-16
• Primary Completion: 2021-07-30
• Study Completion: 2021-10-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Men or women between the ages of 18 and 75
• Clinical diagnosis of autoimmune thyroiditis, serum TPOAb and TGAB positive
• Thyroid function is normal, and no drugs affecting thyroid function such as Umetole and Serge have been used

Exclusion Criteria

• The contraindications indicated in the Chinese instructions of the drug
• Hypothyroidism, hyperthyroidism
• Liver function impairment
• Renal function impairment
• Claustrophobia
• Mental disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
selenium	Selenium	selenium was administered to patients with autoimmune thyroiditis

Primary Outcome Measures

Name	Time	Method
T1-mapping values of Thyroid MRI	Changes from baseline and 3 months during follow-up	Changes from baseline and 3 months during follow-up
anti-thyroglobulin antibody changes	Changes from baseline and 3 months during follow-up	Changes from baseline and 3 months during follow-up

Trial Locations

Locations (1)

Beijing Chao-Yang Hospital, Capital Medical University; 🇨🇳 Beijing, Beijing, China