Prognosis of Inpatients Evaluated for Palliative Radiotherapy

Completed

• Conditions: Cancer

• Registration Number: NCT02312791
• Lead Sponsor: University of Sao Paulo

Brief Summary

Understanding patient's prognosis is of utmost importance to determine radiotherapy's indication and dose/ fractionation. The investigators plan to conduct an observational study of prognosis of inpatients evaluated for palliative radiotherapy at a large cancer hospital in Brazil.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-10-14
• Study Start: 2014-12
• Study First Submitted QC: 2014-12-08
• Study First Posted: 2014-12-09
• Primary Completion: 2017-09
• Status Verified: 2019-01
• Study Completion: 2019-01
• Last Update Submitted: 2019-01-14
• Last Update Posted: 2019-01-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 362

Inclusion Criteria

• All inpatients evaluated for palliative radiation therapy at ICESP (Instituto do Cancer do Estado de Sao Paulo)

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Exclusion Criteria

• Inpatients evaluated whose intent of treatment is curative
• Patients who are unwilling to participate in the study or unwilling to sign informed consent

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall Survival	9 months	Overall Survival in the studied population

Secondary Outcome Measures

Name	Time	Method
Overall Survival by Survival Prognostic Score (SPS)	3 months and 9 months	Patients will be divided into 3 subgroups according to the SPS. Survival differences between the different subgroups will be compared and analyzed
Positive Predictive Value of PPI	3 weeks and 6 weeks	Positive Predictive Value of PPI to predict death at 3 weeks and 6 weeks.
Overall Survival by Palliative Prognostic Index (PPI)	3 months and 9 months	Patients will be divided into 3 subgroups according to the PPI. Survival differences between the different subgroups will be compared and analyzed
Overall Survival in Each Indication of Palliative Radiotherapy	3 months and 9 months	Overall Survival in Each Indication of Palliative Radiotherapy.; The indication will be as follow: * spinal cord compression; * brain metastases; * tumor bleeding; * tumoral mass; * Oncologic Pain; * Superior Vena Cava Syndrome/ Airway compression
Overall Survival by Score Index for Stereotactic Radiosurgery for Brain Metastases (SIR)	3 months and 9 months	Patients will brain metastases will be divided into 3 subgroups according to SIR. They will be divided into SIR 0-3; 4-7;8-10. Survival differences between the different subgroups will be compared and analyzed

Trial Locations

Locations (1)

Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas da Faculdade de Medicina da USP; 🇧🇷 Sao Paulo, Brazil