Effect of i-Coll- collagen particles on wound healing dynamics of chronic leg ulcers.

Chronic leg ulcers, including diabetic, venous, and pressure ulcers, are major public health concerns causing significant morbidity, pain, and disability. Delayed healing in such ulcers often results from impaired collagen synthesis and tissue remodeling. Collagen-based therapies have shown promise in enhancing wound repair by supporting cellular proliferation and extracellular matrix formation.

This interventional study aims to evaluate the efficacy of i-Coll collagen particles on wound healing dynamics in patients with chronic leg ulcers. A total of 30 participants with non-healing ulcers of more than three months’ duration will be recruited and receive i-Coll collagen particle application every 48 hours for 21 days, along with standard wound care practices.

The primary outcome is the rate of wound contraction, assessed by planimetric and photographic measurements. Secondary outcomes include hydroxyproline and hexosamine content in wound swab samples, reflecting biochemical markers of collagen synthesis and healing.

It is hypothesized that i-Coll collagen particles, due to their native triple-helical protein structure, will enhance granulation tissue formation, accelerate epithelialization, and promote faster wound closure compared to standard treatment. The findings are expected to provide evidence for the therapeutic role of collagen-based formulations in chronic wound management.