Treatment of Hyperuricemia in Patients With Heart Failure

Phase 4

Completed

• Conditions: Hyperuricemia; Heart Failure

• Registration Number: NCT00422318
• Lead Sponsor: Tottori University Hospital

Brief Summary

The study aims to assess (I) the contribution of UA itself to the CHF pathophysiology and (II) to test the effect of lowering UA by uricosuric treatment in CHF.

Detailed Description

Hyperuricemia is often observed in patients with congestive heart failure (CHF). It has been reported that hyperuricemia is related to exercise capacity, inflammation markers and diastolic dysfunction in such patients. In addition, hyperuricemia in CHF relates to both symptomatic status (i.e. morbidity) as well as impaired prognosis (i.e. mortality). Hyperuricemia is likely to play an important role in the pathophysiology of CHF. Up-regulation of xanthine oxidase (XO) activity in CHF has been shown to contribute to higher uric acid (UA) in CHF and the therapeutic concept of XO inhibition has shown beneficial effects in a number of surrogate markers in these patients. The XO inhibition accounts for substantial decrease in oxygen radical load, the latter is discussed as the main benefit of XO inhibition treatment in hyperuricemic patients. However, whether high uric acid itself is important or merely a marker of XO activity (and hence of increased radical accumulation) is currently under discussion. Therefore, this study aims to assess (I) the contribution of UA itself to the CHF pathophysiology and (II) to test the effect of lowering UA by uricosuric treatment in CHF.

Study Timeline

• Study Start: 2004-01
• Study Completion: 2005-12
• Status Verified: 2007-01
• Study First Submitted: 2007-01-12
• Study First Submitted QC: 2007-01-12
• Last Update Submitted: 2007-01-12
• Study First Posted: 2007-01-15
• Last Update Posted: 2007-01-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• chronic heart failure
• hyperuricemia

Exclusion Criteria

• renal dysfunction (Cr > 2.0 mg/dl)
• under treatment with anti-diabetic agents

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
parameters of echocardiography at 16 weeks
BNP levels at 16 weeks

Secondary Outcome Measures

Name	Time	Method
parameters of glucose metabolism at 16 weeks
Parameters of lipid metabolism at 16 weeks

Trial Locations

Locations (1)

Tottori University Hospital; 🇯🇵 Yonago, Japan