Quercetin as Possible Supportive Therapy for Mild to Moderate Hyperuricemia
- Conditions
- Hyperuricemia
- Interventions
- Combination Product: Berberol K®Dietary Supplement: Quercetin
- Registration Number
- NCT06591767
- Lead Sponsor
- Liaquat University of Medical & Health Sciences
- Brief Summary
Uric acid, a metabolic byproduct of purine degradation in humans, is a known risk factor for conditions such as gout and type 2 diabetes. Research has shown that supplementation with quercetin can significantly reduce plasma uric acid levels in individuals with mild hyperuricemia, potentially mitigating these associated risks.
- Detailed Description
Uric acid, a metabolic byproduct of purine degradation in humans, is a significant risk factor for the development of gout and type 2 diabetes. Supplementation with quercetin, a flavonol not naturally produced by the human body, has been shown to significantly reduce plasma uric acid levels in individuals with mild hyperuricemia. This effect is primarily achieved through the inhibition of xanthine oxidoreductase, an enzyme crucial to uric acid production.
Quercetin is the most abundant polyphenol found in fruits and vegetables and is widely used as a dietary supplement to boost the immune system and promote overall health. It is characterized by three key properties: antioxidant, anti-inflammatory, and immunomodulatory. These combined actions make quercetin a promising candidate for supporting various health conditions where oxidative stress, inflammation, and immune function play a role, including cardiovascular health, healthy aging, bone and joint health, sports and physical activity, gut health, and respiratory well-being.
The above-described properties of quercetin prompted investigators to explore its potential uricosuric therapeutic effect in two clinical studies. The first study will assess this effect in a retrospective cohort of COVID-19 patients who received quercetin as a supplemental therapy. In the second study, its potential uricosuric therapeutic effect will be assessed in a randomized controlled prospective clinical trial involving patients with mild to moderate hyperuricemia.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 64
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control group 1 Berberol K® In this group hyperuricemic patients (uric acid \> 8 mg/dL) received oral supplemental Berberine and monacolins based supplement, twice a day for 90 days. Quercetin group Quercetin In this group hyperuricemic patients (uric acid \> 8 mg/dL) received oral supplemental Quercetin, twice a day for 90 days. Control group 2 Berberol K® In this group normouricemic patients (uric acid \< 7 mg/dL) received oral supplemental Berberine and monacolins based supplement, twice a day for 90 days.
- Primary Outcome Measures
Name Time Method Effect on circulatory uric acid 90 days Change in plasma uric acid level
- Secondary Outcome Measures
Name Time Method Effect on lipids 90 days Change in plasma triglycerides level
Effect on glycemia 90 days Change in plasma insulin level
Effect on body internal organs muscles 90 days Change in the Creatine Phosphokinase (CPK) levels
Effect on liver function 90 days Change in the Bilirubin levels
Supplement safety and tolerability 90 days Number of patients reporting possible side effects
Trial Locations
- Locations (1)
S. Orsola-Malpighi Polyclinic Hospital
🇮🇹Bologna, Italy