Pharmacological Magnetic Resonance Spectroscopy

Amsterdam University Medical Center, location AMC0 个研究点目标入组 30 人开始时间: 待定最近更新: 2024年6月11日

试验速览

暂无简介。

•? Healthy volunteers between 18 and 55 years old;
•? BMI between 18.5 and 25;
•? Male or female;
•? If female: using oral contraceptives and not in hormone-free week during scanning

•? (History of) psychiatric treatment, for which prescription medication is used;
•? First-degree relative with (history of) schizophrenia or major depression;
•? (History) of neurological disorders (including stroke, convulsion, epilepsy) as well as concussion
•with loss of consciousness
•? Contraindications for S-ketamine (e.g. allergy for S-ketamine, or one of the inactive ingredients
•of this product, high BP (RRsystolic > 180 mmHg or diastolic >100 mmHg), use of xantiderivatives
•or methylergometrine); use of substances that interact with S-ketamine (e.g. grapefruit juice, antifungal medication)
•? Contraindications for 7T MRI (e.g. claustrophobia, osteosynthetic material, pacemaker, artificial
•cardiac valves);
•? (History of) drug (opiate, LSD, (meth)amphetamine, cocaine, solvents, cannabis, or barbiturate)
•or alcohol dependence;
•? Used psychotropic medication, or recreational drugs over a period of 1 week prior to each test
•? Used alcohol within the last 24 hours prior to each test session.

发起方

Amsterdam University Medical Center, location AMC