Diagnosis of Laryngopharyngeal Reflux (LPR) in patients with Hoarseness and Globus: is aerosolized oropharyngeal pH monitoring adequate?

Recruiting

• Conditions: aryngofaryngeale Reflux (LFR); Extraesophageal reflux; heartburn; 10031013

• Registration Number: NL-OMON32450
• Lead Sponsor: Sint Lucas Andreas Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

- Patients with haorseness and/or globus, RSI>13 (n<=20)
- Patients without hoarseness and globus, RSI>13 (n<=20)
- Subjects without hoarseness and globus, RSI<13 (n<=20)

Exclusion Criteria

anatomical abnormalities that can explain hoarseness (eg polyp), functional abnormalities that can explain hoarseness (speech therapy related), malignancies, usages of PPI*s or H2 antagonists, pregnancy or lactating, smoking

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>During 24 hours:<br /><br>- mean pH<br /><br>- percentage of time with pH <4.0/4.5/5.0/5.5/6.0/6.5<br /><br>- number of pH events <4.0/4.5/5.0/5.5/6.0/6.5.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>