Effect of nanocurcumin and chlorhexidine mouthwash on level of prostaglandin E2

Phase 2

Recruiting

• Conditions: teeth shifting.; Encounter for other specified aftercare; Z51.8

• Registration Number: IRCT20220223054108N2
• Lead Sponsor: Gorgan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 June 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

Agreement to participation in the study
15 to 35 years old
Passed at least 2 mounts after fixed orthodontics treatment
Negative for hypersensitivity to Curcumin and/or chlorhexidine

Exclusion Criteria

The presence of any ulcer or intraoral infection
Severe gingival inflammation or periodontal pocket
Systemic disease
Pregnant and lactating mothers
Antibiotics usage in a month before the study
Fluoride therapy in the last 6 months
Tobacco usage
Corticosteroids and NSAIDs usage

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prostaglandin E2 before and two weeks later in all studied groups. Timepoint: Measurement of prostaglandin E2 at the study's baseline (before starting treatment) and two weeks after consuming the prescribed mouthwashes for each group. Method of measurement: Enzyme-linked Immunosorbent Assay (ELISA test).

Secondary Outcome Measures

Name	Time	Method
Patients' perception of taste in the group of patients using prescribed mouthwashes. Timepoint: The seventh day after using the prescribed mouthwashes. Method of measurement: Individually asking each of the participants about the taste of the prescribed mouthwash based on a questionnaire to check the quality of mouthwash.