Assessing the effect of nanomisel curcumin on prevention and treatment of nanomisel curcumi
- Conditions
- Oral Candidiasis.Candidal stomatitis/Oral thrushB 37.0
- Registration Number
- IRCT20180416039318N3
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
the minimum age of 18 years, presence of head and neck cancer, radiation dose of 50-70 Gy, at least 50% of patient’s oral cavity in the field of radiation and patient satisfaction.
previous history of radiation therapy, patient dissatisfaction, history of allergy to turmeric, , in case of any oral lesions or complication resulting from radiation therapy other than candidiasis and mucositis, use of systemic or topical antifungal drugs for any reason, pregnancy or breastfeeding periods in women under treatment, presence of local and systemic conditions predisposing for candidiasis, such as the application of inhaled and topical steroids, presence of hyperkeratosis, use of immunosuppressive drugs, history of systemic antibiotic usage over the previous 2 weeks, the presence of CFU above 400/ml in the first culture or clinical evidence based on the presence of oral candidiasis.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ccurrence of oral candidiasis. Timepoint: The first day of radiotherapy before radiation, every week until the end of the study. Method of measurement: Clinical examinations of oral lesion.;Candidate colony count in ml (colony forming unit = CFU). Timepoint: before the study, in the third week and the final week of radiotherapy. Method of measurement: Cultivation of oral lesions.
- Secondary Outcome Measures
Name Time Method Type of oral Candidiasis. Timepoint: before the study, in the third week and the final week of radiotherapy. Method of measurement: germ tube test and cultivation of oral lesions.