Investigating the effect of nanocurcumin in psychotic methamphetamine users
- Conditions
- Psychotic methamphetamine users.???????? ????? ? ?????? ???? ?? ???? ???? ?????????F10-F19
- Registration Number
- IRCT20240208060938N1
- Lead Sponsor
- Kashan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 50
Being at least 18 years old based on symptoms of methamphetamine psychosis to be admitted to the psychiatric ward.
Use of methamphetamine more than two days a week for more than 1 year, as dependent on methamphetamine.
Diagnosis of chronic methamphetamine use disorder based on the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition
Based on the diagnosis of the senior research psychiatrist, having the symptoms of methamphetamine psychosis to be admitted to the psychiatric ward, one of the criteria of which is the positive and negative syndrome (PANSS), which was initially created for use in patients with schizophrenia, is one of the most reliable tools to assess the existence and the severity of psychotic symptoms.
Having a minimum score of 10 and a maximum score of 70 for drug craving based on the questionnaire measuring the momentary drug craving (DDQ) to enter the intervention.
People should not have a history of drug use (opium, opium juice, heroin, crack, and hashish).
Completing the consent form.
Unwillingness to cooperate at any stage of project implementation.
Be dependent on drugs other than methamphetamine.
People who are allergic to study and report side effects caused by taking medicine while studying.
Taking curcumin and antioxidant and anti-inflammatory supplements in the last 3 months.
The urine test for morphine, hashish and other drugs except methamphetamine will be checked three times for each person during the study, and if the test is positive, the patient will be excluded from the study.
Pregnant women.
Any past or current psychotic disorder, including manic episodes, schizophrenia, and schizoaffective disorder.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Methamphetamine dependence and craving score. Timepoint: At the beginning of the study (before the start of the intervention) and at the end of the study, 4 weeks after taking nanocurcumin and one month later without drug intervention. Method of measurement: Craving score is used to measure craving through visual analog scales (VAS).
- Secondary Outcome Measures
Name Time Method