Comparison of Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography (PET) scan vs Fludeoxyglucose (FDG) PET scan when assessing for spread of kidney tumours

Not Applicable

Recruiting

• Conditions: Renal tumours; Cancer - Kidney

• Registration Number: ACTRN12624000155594
• Lead Sponsor: Metro North HHS

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-02-16
• Last Update Posted: 15 July 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Aged 18 years or older
Renal tumours >7cm, or cT3/4 and/or cN1 or equivocal retroperitoneal lymph node involvement on CT
M0 or equivocal on CT chest, abdomen, pelvis within 6 weeks prior to recruitment
Able to provide informed consent
Willing and able to comply with study protocol ; Aged 18 years or older
Renal tumours >7cm, or cT3/4 and/or cN1 or equivocal retroperitoneal lymph node involvement on CT
M0 or equivocal on CT chest, abdomen, pelvis within 6 weeks prior to recruitment
Able to provide informed consent
Willing and able to comply with study protocol

Exclusion Criteria

History of other active malignancy within last 2 years, excluding non-melanoma cutaneous neoplasms
Renal tumours having an atypical appearance where an alternative diagnosis is felt to be more likely eg urothelial carcinoma
PSMA or FDG PET in the preceding 2 years.
Significant co-morbidity or other barrier to completing study processes
Patients with renal masses with IVC tumour thrombus if awaiting PET scans will cause unnecessary surgical delay
Pregnancy, or planning pregnancy in the next 6 months. ; History of other active malignancy within last 2 years, excluding non-melanoma cutaneous neoplasms
Renal tumours having an atypical appearance where an alternative diagnosis is felt to be more likely eg urothelial carcinoma
PSMA or FDG PET in the preceding 2 years.
Significant co-morbidity or other barrier to completing study processes
Patients with renal masses with IVC tumour thrombus if awaiting PET scans will cause unnecessary surgical delay
Pregnancy, or planning pregnancy in the next 6 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of patients whose management is changed by addition PSMA to conventional CT scan. [Patient medical records 21 (+/- 7) days following enrollment];Proportion of patients whose management is changed by addition FDG PET to conventional CT scan. [Patient medical records 21 (+/- 7) days following enrollment];Proportion of patients whose management is changed by addition PSMA to conventional CT scan. [Patient medical records 21 (+/- 7) days following enrollment];Proportion of patients whose management is changed by addition FDG PET to conventional CT scan. [Patient medical records 21 (+/- 7) days following enrollment]