Effect of Interscalene Block on Intraocular Pressure and Ocular Perfusion Pressure in Upper Limb Surgeries: An Observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Intraocular Pressure
研究概览
简要总结
TITLE :EFFECT OF INTERSCALENE BLOCK ON INTRAOCULAR PRESSURE AND OCULAR PERFUSION PRESSURE IN UPPER LIMB SURGERIES: AN OBSERVATIONAL STUDY.
Keywords: Interscalene Block, Ocular Perfusion Pressure, Intraocular pressure, Mean arterial pressure.
Introduction:. Interscalene block(ISB) causes changes in Intraocular pressure(IOP) and Ocular perfusion pressure(OPP) as it blocks cervical sympathetic ganglia innervating ciliary blood vessels which are major source of Aqueous humour production.
Methods: After Institutional Ethical Clearance(KIMS/IEC/A152/M/2024), Prospective observational study for period of 6 months, with sample size 80 (80 eyes=40 patients) will be started. ASA I, II patients aged 18-60 posted for elective upper limb surgeries will be included after excluding glaucoma, cataract and patients contraindicated for ISB.
Under USG guidance, ISB will be performed and Local anaesthetic=10ml Lignocaine(21.3mg/ml)+Adrenaline(0.005mg/ml)+10ml 0.5% Bupivacaine(5mg/ml) would be administered.
Post ISB Intraocular pressure (IOP) will be measured periodically using Easyton Trans-palpebral tonometer, on blocked side(case) and unblocked side(control eye) along with mean arterial pressure(MAP).
OPP will be calculated using equation ,OPP=(95/140*MAP)-IOP.
Repeated measures ANOVA will be used to test IOP and OPP difference in the blocked and unblocked eye at every 5 minutes after ISB (this will be done as per the planned time periods ).
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients posted for elective upper limb surgeries.
- •Also, Patients belonging to ASA 1 and 2 according to American Society of Anaesthesiologists Physical status classification.
排除标准
- •Patients already diagnosed to have glaucoma, cataract.
- •Patients with contraindications to brachial plexus blocks (coagulopathies, severe respiratory disease, contralateral phrenic nerve paralysis).
- •Patients diagnosed to have Horner’s syndrome in the past or bell’s palsy or diagnosed to have stroke or head injury in the past.
- •Patients proved to have allergic/ hypersensitivity to local anaesthetics.
- •Pre-existing acute or chronic eye disease or had eye injury /penetrating ocular injury in the past or had history of eye surgery
- •Use of ß blockers, Ca channel blockers, statins and nitrates which influence IOP
- •Pregnant females .
- •Patients who refuse to take part in study.
结局指标
主要结局
Intraocular Pressure
时间窗: 0,5,10,15,20,25,30,35,40,45,50,55,60th Minute
次要结局
- Ocular Perfusion Pressure(0,5,10,15,20,25,30,35,40,45,50,55,60th Minute)
研究者
Dr Ashwini A
Kempegowda Institute of Medical Sciences , Bangalore, Karnataka, India