COMPARISON OF PALANOSETRON AND ONDANSETRON ON ONSET OF POSTCRANIOTOMY NAUSEA AND VOMITING (POO-PCNV) TRIAL

PONV( Post operative nausea and vomiting) is a frequent and distressing symptom after any type of neurosurgial procedure with a reported incidence of 44-70% in diffrent studies.In addition to cuasing patient discomfort  protracted PONV causes dehdration, acid-base disturbance, electrolyte imbalance which may effect the cerebral physiology and influence the outcome of the patient. Selective serotonin(5HT-3) antagonists are considered first choice for PONV owing to their safe profile and lack of serious side effects. Palanosetron have been found to be superioir to other serotonin anatgonists in phase 3 clinical trials in reducing early, immediate and delayed chemotherapy induced vomiting. No study has yet been done to evaluate the efficacy of palanosetron in the neurosurgical pouplation. Thus we planned  a prospetive randomized, double blind , controlled clinical trial to compare the efficacy of ondansetron and palanosetron in reducing PONV in patients undergoing neurosurgery. We will also assess corerelation of PONV with other factors sich as midline shift, mass effect, site and pathologic diagnosis of the tumour.