Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Acute Coronary Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Evaluate the diagnostic value of microRNAs in qPCR，in ACS
研究概览
简要总结
The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for suspected ACS patients at the emergency department (ED) and intensive care unit (ICU).
详细描述
The present study is a single-center, prospective diagnostic study among patients presenting to the ED or ICU within 24 h of onset of chest pain suggestive of suspected ACS.
We propose to construct the biobank of ACS and evaluate the potential diagnostic value of circulating microRNAs compared with cTnI for suspected ACS patients. All the patients are to be followed up for 6 months. Final diagnosis was made by an expert panel cardiologist, based on all available clinical information including cTnI measurements, ECG, coronary angiography, cardiac exercise tests and information from hospital discharge letters.
The concentrations of microRNAs will be evaluated by quantitative reverse transcription PCR, using highly specific primers and hybridization probes.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Suspected ACS patients (STEMI, NSTEMI, and UA):
- •Age>18 years; Informed consent.
排除标准
- •Patients who will undergo immediate PCI; Pregnant and lactating women; Patients with mental disorders; Patients are using other experimental drugs; Refusal to provide informed.
结局指标
主要结局
Evaluate the diagnostic value of microRNAs in qPCR，in ACS
时间窗: Day 7
次要结局
- Evaluate the prognostic value of microRNAs in ACS(6 months)
研究者
Bin He
M.D./Ph.D.
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine