Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Sepsis-induced Myocardial Injury
- Conditions
- Sepsis-induced Myocardial Injury
- Registration Number
- NCT02835573
- Brief Summary
The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for the patients of sepsis-induced myocardial injury at the emergency department (ED) and intensive care unit (ICU).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Diagnosis of sepsis:SOFA score increase >=2 at baseline level induced by infection.
- Suspected myocardial injury,including 1 as follows at least:Low blood pressure or using vasoactive drugs; ECG changes(ST segment changes or pathological Q wave); Troponin elevation(> 0.5 μg/L); BNP elevation(> 4670pg/ml); Echocardiography: cardiac function decline(EF<50%).
Exclusion Criteria
- Skeletal muscle damage (induced by orthopedics, vascular surgery or trauma surgical disease, surgery);
- Pregnant and lactating women;
- Patients with mental disorders;
- Patients are using other experimental drugs;
- Refusal to provide informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diagnostic value of microRNAs evaluate by qPCR in patients of sepsis-induced myocardial injury Day 7
- Secondary Outcome Measures
Name Time Method Prognostic value of microRNAs in patients of sepsis-induced myocardial injury 6 months
Trial Locations
- Locations (1)
Ethics Committee of Xinhua Hospital
🇨🇳Shanghai, Shanghai, China