Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Acute Coronary Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Coronary Syndrome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Evaluate the diagnostic value of microRNAs in qPCR，in ACS
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for suspected ACS patients at the emergency department (ED) and intensive care unit (ICU).
Detailed Description
The present study is a single-center, prospective diagnostic study among patients presenting to the ED or ICU within 24 h of onset of chest pain suggestive of suspected ACS. We propose to construct the biobank of ACS and evaluate the potential diagnostic value of circulating microRNAs compared with cTnI for suspected ACS patients. All the patients are to be followed up for 6 months. Final diagnosis was made by an expert panel cardiologist, based on all available clinical information including cTnI measurements, ECG, coronary angiography, cardiac exercise tests and information from hospital discharge letters. The concentrations of microRNAs will be evaluated by quantitative reverse transcription PCR, using highly specific primers and hybridization probes.
Investigators
Bin He
M.D./Ph.D.
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility Criteria
Inclusion Criteria
- •Suspected ACS patients (STEMI, NSTEMI, and UA):
- •Age\>18 years; Informed consent.
Exclusion Criteria
- •Patients who will undergo immediate PCI; Pregnant and lactating women; Patients with mental disorders; Patients are using other experimental drugs; Refusal to provide informed.
Outcomes
Primary Outcomes
Evaluate the diagnostic value of microRNAs in qPCR，in ACS
Time Frame: Day 7
Secondary Outcomes
- Evaluate the prognostic value of microRNAs in ACS(6 months)