The Effect of Resistance Exercise on Inflammation in Young and Older Adults

Not Applicable

Completed

• Conditions: Inflammatory Response; Aging
• Interventions: Other: Resistance exercise

• Registration Number: NCT05042167
• Lead Sponsor: National Taiwan Normal University

Brief Summary

Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-09-02
• Study First Submitted QC: 2021-09-10
• Study First Posted: 2021-09-13
• Study Start: 2021-10-01
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-12
• Last Update Posted: 2023-01-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 16

Inclusion Criteria

• Age: 20-80
• Healthy male
• Without experience of resistance training

Exclusion Criteria

• No acute or chronic musculoskeletal symptoms
• Smoking
• Alcohol or drug abuse
• Fail to conduct resistance exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High-load resistance exercise	Resistance exercise	Subjects in high-load trial performed 3 sets per exercise, 8 repetitions with load of 70%-1RM with 90 sec of rest between sets, followed by a fourth set to voluntary failure.

Primary Outcome Measures

Name	Time	Method
Changes in biomarkers of inflammation	24-hour during each study intervention	Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL.

Secondary Outcome Measures

Name	Time	Method
Changes in glucose	24-hour during each study intervention	glucose in mg/dL
Changes in biomarkers of muscle damage	24-hour during each study intervention	Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.
Changes in complete blood count (CBC)	24-hour during each study intervention	The white blood cell count and the count of each white blood cell type will be measured.
Changes in metabolic parameters	24-hour during each study intervention	Metabolic parameters will be measured such as TC in mg/dL, TG in mg/dL, and HDL in mg/dL.
Changes in molecular markers in peripheral blood mononuclear cells (PBMC)	24-hour during each study intervention	Molecular markers in PBMC will be measured such as STAT3 in arbitrary units, IKK in arbitrary units, IkB in arbitrary units, p65 in arbitrary units, SOCS3 in arbitrary units, AMPK in arbitrary units, and SIRT1 in arbitrary units.
Borgs Ratings of Perceived Exertion (RPE)	1-hour during each exercise intervention	Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).

Trial Locations

Locations (1)

National Taiwan Normal University; 🇨🇳 Taipei, Taiwan