The Acute Effect of High-load Resistance Exercise on Inflammation in Young and Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Changes in biomarkers of inflammation
研究概览
简要总结
Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected.
The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age: 20-80
- •Healthy male
- •Without experience of resistance training
排除标准
- •No acute or chronic musculoskeletal symptoms
- •Alcohol or drug abuse
- •Fail to conduct resistance exercise
研究组 & 干预措施
High-load resistance exercise
Subjects in high-load trial performed 3 sets per exercise, 8 repetitions with load of 70%-1RM with 90 sec of rest between sets, followed by a fourth set to voluntary failure.
干预措施: Resistance exercise (Other)
Sedentary control
Subjects in control trial stayed sedentary during the period.
结局指标
主要结局
Changes in biomarkers of inflammation
时间窗: 24-hour during each study intervention
Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL.
次要结局
- Borgs Ratings of Perceived Exertion (RPE)(1-hour during each exercise intervention)
- Changes in glucose(24-hour during each study intervention)
- Changes in biomarkers of muscle damage(24-hour during each study intervention)
- Changes in complete blood count (CBC)(24-hour during each study intervention)
- Changes in metabolic parameters(24-hour during each study intervention)
- Changes in molecular markers in peripheral blood mononuclear cells (PBMC)(24-hour during each study intervention)