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Clinical Trials/NCT02281331
NCT02281331CompletedNot Applicable

Evaluation of the Effects of a Combined Resistance and High-intensity Interval Exercise Training Program, Along With Nutritional Supplementation, on Strength and Physical Function in Older Men

McMaster University1 site in 1 country50 target enrollmentStarted: October 1, 2014Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
50
Locations
1
Primary Endpoint
Muscle mass

Study Overview

Brief Summary

As we age we tend to lose muscle mass and strength. These losses contribute to the increased incidence of falls and fractures, metabolic diseases such as type 2 diabetes, loss of independence and reduced quality of life in the elderly. As the number of seniors increases worldwide, it is becoming more and more important to develop strategies to counteract this loss of muscle mass and strength, and promote healthy aging. Fortunately, relatively simple lifestyle modifications are the most potent defense strategies. Exercises such as weight lifting and high-intensity interval exercise (HIIT), which consists of short, repeated bouts of vigorous aerobic exercise interspersed with period of rest, are the most effective in promoting gains in muscle mass and strength. Additionally, components of foods like whey (a protein found in milk), creatine (found in meat), calcium and vitamin D have been shown to independently increase strength. In this study, we are looking to determine how much we can increase muscle strength in older men who are put on an 12 week exercise training program that combines weight lifting and HIIT, and who consume a daily supplement that contains whey protein, creatine, calcium and vitamin D.

Detailed Description

Please see other documentation.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Prevention
Masking
Double (Participant, Investigator)

Eligibility Criteria

Ages
60 Years to — (Adult, Older Adult)
Sex
Male
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Sedentary (no participation in a structured exercise training program in past 6 months)
  • •BMI between 18.5-30.0 kg/m2
  • •Weight stable for past 6 months
  • •Normal resting blood pressure, or stage I hypertension

Exclusion Criteria

  • •Use of simvastatin or atorvastatin
  • •Use of non-steroidal anti-inflammatory drugs
  • •Injuries that prevent safe-participation in an exercise training program
  • •Prescription blood thinners
  • •Diabetes or other metabolic disorders
  • •Cardiac or gastro-intestinal problems
  • •Infectious disease or cancer

Arms & Interventions

Supplement

Active Comparator

Each day, participants in this group will receive a supplement that provides a total of protein, creatine monohydrate, calcium, vitamin D and carbohydrate. This supplement will be provided to participants in beverage format, twice daily.

Intervention: Supplement (Dietary Supplement)

Placebo

Placebo Comparator

The placebo will provide participants with maltodextrin (carbohydrate) and sucrose.

Intervention: Supplement (Dietary Supplement)

Outcomes

Primary Outcomes

Muscle mass

Time Frame: 12 weeks

DXA, ultrasound

Secondary Outcomes

  • Muscle protein synthesis(12 weeks)
  • Satellite cell number, density, type I/type II fibre specific satellite cells and myonuclear domain(12 weeks)
  • Glycemic control(12 weeks)
  • Cognitive function(12 weeks)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Stuart Phillips

Principal Investigator

McMaster University

Study Sites (1)

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