Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Mayo Clinic
- Enrollment
- 67
- Locations
- 1
- Primary Endpoint
- Skeletal Muscle Protein Synthesis
Study Overview
Brief Summary
Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic disorders and frailty of the investigators rapidly expanding aging population. Endurance (aerobic) and resistance exercise training programs have been shown to effectively reverse the age-related decline in metabolic and contractile muscle functions. The investigators will measure synthesis rates of individual muscle proteins in 36 each of young (18-30 yrs) and 36 older (> 65 yrs) people to determine their response to 8 weeks each of endurance, resistance, combined endurance and resistance training, or placebo exercise training.
Hypotheses.
- to measure fractional synthesis rates of multiple muscle proteins and identify those that are enhanced by an endurance exercise program
- to determine whether changes in protein synthesis in response to endurance exercise programs are dependent on age
- to measure fractional muscle synthesis rates of multiple muscle proteins and to identify those that are enhanced by a resistance exercise program
- to determine whether changes in protein synthesis in response to resistance exercise programs are dependent on age
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •18 to 30 or >65 years
- •Males and Females
Exclusion Criteria
- •Regular Exercise Program
- •Cardiometabolic Disease (diabetes, cardiovascular disease, thyroid disorders)
- •Drugs known to impair metabolic function (beta blockers, steroids)
- •Allergies to lidocaine
- •Physical disability that precludes exercise
Arms & Interventions
Endurance Exercise
Participants will perform 8-weeks of moderate intensity endurance (cycling) exercise
Intervention: Endurance exercise (Behavioral)
Resistance Exercise
Participants will perform 8-weeks of whole-body resistance exercise training.
Intervention: Resistance exercise (Behavioral)
Control / Combined Training
Participants will perform 8-weeks of no exercise, followed by an additional 8-weeks of combined endurance plus resistance exercise training.
Intervention: Control/Combined training (Behavioral)
Outcomes
Primary Outcomes
Skeletal Muscle Protein Synthesis
Time Frame: Measured at week 0 (baseline) and week 8
The investigators will determine the change from baseline in skeletal muscle protein synthesis. Measurments will be performed at baseline and following 8 weeks of exercise training.
Secondary Outcomes
- Mitochondrial Function(Measured at week 0 (baseline) and week 8)
Investigators
K. Sreekumaran Nair
Professor of Medicine
Mayo Clinic