Optimisation and regulation of breathing in heart failure

Not Applicable

Completed

• Conditions: Topic: Diabetes Research Network; Subtopic: Type 2; Disease: Cardiovascular disease; Circulatory System; Heart failure

• Registration Number: ISRCTN29344450
• Lead Sponsor: Imperial College London (UK)

Brief Summary

2014 dynamic CO2 therapy results in https://pubmed.ncbi.nlm.nih.gov/25332798/ (added 29/12/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-05-06
• Study Completion: 2010-09-30
• Last Update Posted: 11 January 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

1. Aged 18 - 80 years, either sex
2. Chronic systolic heart afilure confirmed by transthoracic echo

Exclusion Criteria

1. Severe lung disease
2. Any condition that would preclude participants from lying comfortably on a couch for the duration of the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> All parameters are measured continuously throughout the recordings:<br> Substudy 1: the effect on blood pressure of changes in AV and VV delay of a pacemaker<br> Substudy 2: the size of the change in end tidal carbon dioxide and ventilation achievable from a change in pacemaker setting and the application of dynamic CO2<br> Substudy 3: the size of the change in ventilation achievable from administration of CO2<br>

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures