sing ketamine (an anesthetic agent) with Propofol (a hypnotic agent commonly used during sedation) during visual examination of large intestine reduces propofol dosage improves the quality of sedatio

Phase 4

Completed

• Conditions: Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Anaesthesiology - Other anaesthesiology; Patients undergoing colonoscopy under sedation

• Registration Number: ACTRN12612000162819
• Lead Sponsor: Prof. Mehmet Ayhan KUZ

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-02-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

ASA I-II patients undergoing colonoscopy under sedation

Exclusion Criteria

Use of anti-anxiety medicine within 48 hours before the procedure, past history of anorectal, colonic and gynecologic surgery and complaint of pain at the anal area precluding examination

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The amount of propofol used during sedation in each groups. Total propofol dosage used during all procedures will be recorded after the procedures are completed.[After the procedure];Quality of Sedation<br>Assessed both by patients with questionniares and by the endoscopists.[Questionnaires were performed to patients before discharging and 24 hours after the procedure.<br>Endoscopist was asked to evaluate the quality of sedation at the end of the procedure between 0 and 10 (0: worst and 10:best)]

Secondary Outcome Measures

Name	Time	Method
Frequency of adverse events such as apnea, bradycardia, hypotension, nausea, vomiting, agitation, dreaming. The patients will be observed for the adverse events after the procedure until discharge. Therefore clinical assessment will be used.[During and after the procedure];Recovery time;<br>Time to spontaneous eye opening, time to discharge and aldrette scores.<br>The aldrete score is a score of 1 through 10 assessing a patient after anesthesia for discharge criteria. The Aldrete score assesses level of consciousness, respirtory status, circulatory status, activity and oxygen saturation[After the procedure<br>Aldrette scores were recorded at 2.5 minutes intervals after the procedure]