Examining the effect of the anti inflammatory medicine prednisolone on physical performance in patients with COPD and changes in immune response after exercise
- Conditions
- To investigate the effects of prednisone and Solu-Medrol on physical performance in patients with chronic obstructive pulmonary disease(COPD). Furthermore to examine the inflammatory response during and after exercise in patients with COPDTherapeutic area: Diseases [C] - Respiratory Tract Diseases [C08]
- Registration Number
- EUCTR2012-004503-13-DK
- Lead Sponsor
- Bispebjerg Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- Male
- Target Recruitment
- 14
Inclusion Criteria
sex: male
age 40-75
FEV1<60%
In a physical conditíon that allows cycling
smoker or ex smoker
informed consent
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 7
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 7
Exclusion Criteria
haemodynamicaly unstable heart conditions ie heart failure, atrial fibrilation and angina pectoris
other respiratory diseases
cancer the last 5 years
treatment with beta blockers
allergi to study medication
insuline treated diabetes
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: The purpose of this trial is to investigate the effects of the drugs prednisone and Solu-Medrol on physical performance in patients with COPD;Secondary Objective: To examine the inflammatory response during and after exercise in patients with COPD;Primary end point(s): prednisone and solumedrol improves cycling performance;Timepoint(s) of evaluation of this end point: 1,5 years from first participant
- Secondary Outcome Measures
Name Time Method Secondary end point(s): prednisonae and Solu-Medrol improves muscle power. to examine the inflammatory response during exercise during treatment with glucocorticoids;Timepoint(s) of evaluation of this end point: 1,5 years