Understanding the Genetic Predisposition to the Development of Primary Biliary Cirrhosis (PBC).
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- Mapping of Susceptibility Genes in Adult Chronic Cholestatic Liver Diseases
研究概览
简要总结
Primary Biliary Cirrhosis (PBC) is a progressive liver disorder of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PBC.
This study is being done to investigate whether genes make people more likely to develop PBC. Discovery of these proposed genes will help us better understand how PBC developes, and subsequently, to apply new approaches for its prevention, diagnosis and treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women between the ages of 18-90 who have a history of PBC.
- •PBC patients who have undergone a liver transplant are eligible.
- •Family members (1st degree relatives) of enrolled PBC patients are eligible.
排除标准
- •Individuals with no history of PBC or those unable to provide consent.
结局指标
主要结局
Mapping of Susceptibility Genes in Adult Chronic Cholestatic Liver Diseases
Adult chronic cholestatic liver diseases, such as Primary Biliary Cirrhosis (PBC), are progressive liver disorders of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PBC. This study is being done to investigate whether genes (the inherited genetic material passed from parents to their children) make people more likely to develop PBC. Discovery of these proposed genes will help us to better understand how PBC progresses, and subsequently, to apply new approaches for its prevention, diagnosis and treatment.
次要结局
未报告次要终点
研究者
Konstantinos N. Lazaridis, M.D.
Hepatology Consultant
Mayo Clinic