Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)

Active, not recruiting

• Conditions: Primary Biliary Cirrhosis

• Registration Number: NCT01161953
• Lead Sponsor: Mayo Clinic

Brief Summary

Primary Biliary Cirrhosis (PBC) is a progressive liver disorder of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PBC.

This study is being done to investigate whether genes make people more likely to develop PBC. Discovery of these proposed genes will help us better understand how PBC developes, and subsequently, to apply new approaches for its prevention, diagnosis and treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2002-03
• Study First Submitted: 2010-07-12
• Study First Submitted QC: 2010-07-13
• Study First Posted: 2010-07-14
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-14
• Last Update Posted: 2024-03-15
• Primary Completion: 2050-12
• Study Completion: 2050-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

• Men and women between the ages of 18-90 who have a history of PBC.
• PBC patients who have undergone a liver transplant are eligible.
• Family members (1st degree relatives) of enrolled PBC patients are eligible.

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Exclusion Criteria

• Individuals with no history of PBC or those unable to provide consent.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mapping of Susceptibility Genes in Adult Chronic Cholestatic Liver Diseases		Adult chronic cholestatic liver diseases, such as Primary Biliary Cirrhosis (PBC), are progressive liver disorders of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PBC.; This study is being done to investigate whether genes (the inherited genetic material passed from parents to their children) make people more likely to develop PBC. Discovery of these proposed genes will help us to better understand how PBC progresses, and subsequently, to apply new approaches for its prevention, diagnosis and treatment.

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States