NL-OMON53722招募中不适用
Role of the central brain clock in the pathophysiology of insulin resistance - Brain Clock and Insulin Resistance
Amsterdam UMC0 个研究点目标入组 30 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Group 1: obese people with normal insulin sensitivity
- •age 25-65 years
- •fasting plasma insulin <=62 pmol/L
- •fasting plasma glucose <5.6 mmol/L
- •HOMA-IR <= 4.5
- •Group 2: obese people with insulin resistance
- •age 25-65 years
- •fasting plasma insulin >62 pmol/L
- •fasting plasma glucose >=5.6 mmol/L
- •not fulfilling the ADA criteria for type 2 DM
- •Group 3: obese subjects with overt type 2 DM
- •age 25-65 years
- •diagnosis type 2 DM according to ADA criteria
排除标准
- •An extreme chronotype (midpoint of sleep on free days (MSFsc) before 2:00 or
- •after 6:00).
- •Active psychiatric disorder (including circadian rhythm sleep disorder) as
- •defined in DSM 5
- •Disorders of the central nervous system (Early-onset dementia, stroke,
- •epilepsy, Parkinson*s disease, brain tumour)
- •Severe visual impairment (WHO classification)
- •Shift workers
- •Crossing > 2 time zones in the 3 months before the study
- •Patients with type 2 DM receiving insulin treatment or GLP-1 agonists
- •MRI safety and contraindications
- •o The presence of MRI-incompatible metal implants or devices:
- •o Claustrophobia
- •o Pregnancy
- •o Waist circumference or shoulder circumference >155 cm
- •o Body weight > 200 kg
- •o Inability to walk up a staircase independently
研究者
相似试验
已完成
不适用
Brain Clock and Insulin ResistanceType 2 DiabetesInsulin ResistanceNCT05314855Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)28
已完成
不适用
The effects of physical exercise on the brain and the immune system in individuals with chronic pain.Whiplash Associated DisorderChronic PainMusculoskeletal - Other muscular and skeletal disordersNeurological - Other neurological disordersACTRN12619000629134The University of Queensland16
已完成
不适用
The Role of the Circadian System in Neurological Sleep-wake DisordersNarcolepsy 1Idiopathic HypersomniaNCT03356938Esther Werth36
尚未招募
1 期
on-drug treatment program-mechanism-based neurological function rehabilitatioHealthy subjectsITMCTR1900002622Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine
已完成
不适用
CHRONOtype-adjusted DIET on Weight LossObesityNCT03755674Universidad Católica San Antonio de Murcia96