NL-OMON53722
Recruiting
Not Applicable
Role of the central brain clock in the pathophysiology of insulin resistance - Brain Clock and Insulin Resistance
Amsterdam UMC0 sites30 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- De perfusie/activiteit van de centrale hersenklok (SCN)
- Sponsor
- Amsterdam UMC
- Enrollment
- 30
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Group 1: obese people with normal insulin sensitivity
- •age 25\-65 years
- •fasting plasma insulin \<\=62 pmol/L
- •fasting plasma glucose \<5\.6 mmol/L
- •HOMA\-IR \<\= 4\.5
- •Group 2: obese people with insulin resistance
- •age 25\-65 years
- •fasting plasma insulin \>62 pmol/L
- •fasting plasma glucose \>\=5\.6 mmol/L
- •not fulfilling the ADA criteria for type 2 DM
Exclusion Criteria
- •An extreme chronotype (midpoint of sleep on free days (MSFsc) before 2:00 or
- •after 6:00\).
- •Active psychiatric disorder (including circadian rhythm sleep disorder) as
- •defined in DSM 5
- •Disorders of the central nervous system (Early\-onset dementia, stroke,
- •epilepsy, Parkinson\*s disease, brain tumour)
- •Severe visual impairment (WHO classification)
- •Shift workers
- •Crossing \> 2 time zones in the 3 months before the study
- •Patients with type 2 DM receiving insulin treatment or GLP\-1 agonists
Outcomes
Primary Outcomes
Not specified
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